Depression and stress levels increase risk of liver disease, hepatitis

Depression and stress levels increase risk of liver disease, hepatitisDepression, anxiety and stress levels have been shown to increase the risk of death by liver disease. The findings come from the University of Edinburgh, and it’s the first study to identify a possible link between psychological distress and death resulting from various forms of liver disease.

The researchers are still unsure as to the biological link between psychological distress and liver disease. Previous research showed a strong link between mental distress and cardiovascular disease.


Furthermore, risk factors of cardiovascular disease, such as obesity and high blood pressure, are also risk factors for liver disease.

Researchers examined responses from over 165,000 people who answered questionnaires capturing psychological distress. These participants were then tracked over the course of 10 years with a strong focus on the cause of any deaths.

Those who scored high with symptoms of psychological stress were more likely to die from liver disease compared to those with lower scores.

Research lead, Dr. Tom Russ, said, “This study provides further evidence for the important links between mind and body, and of the damaging effects psychological distress can have on physical wellbeing. While we are not able to confirm direct cause and effect, this study does provide evidence that requires further consideration in future studies.”

Cortisol, stress hormone and fatty liver

Cortisol, stress hormone and fatty liverIn other research it was found that cortisol – the stress hormone – could increase the risk of a fatty liver. The study, published in Clinical Endocrinology, found a link between cortisol levels in men and fatty liver disease. Fatty liver disease occurs when too much fat forms around or in the liver, thus negatively affecting the liver’s function.

Researchers found those with non-alcoholic fatty liver disease (NAFLD) had an overproduction of cortisol. Researchers believe that overproduction of cortisol is what contributes to the excess fat in the liver as cortisol is known to promote fat deposits in the liver.

Excessive cortisol is not only harmful for the liver, but it can wreak havoc on your body and overall health. Researchers suggest that if high cortisol levels can contribute to fatty liver, lowering cortisol can diminish fatty liver.

Stress and chronic hepatitis

Numerous studies also point to the association between stress, more specifically psychosocial stress, and the development of viral hepatitis. In one study researchers found a link between psychosocial stress and the severity of chronic hepatitis C. In individuals with low self control, object dependence of loss, unfulfilled need for acceptance and altruisms (Type 1 personality), researchers found more susceptibility to psychosocial stress, which was linked to hepatitis C severity.


Other studies have found that psychosocial stress affects antibody response after a hepatitis B vaccination. One survey revealed that those with higher responses that indicated stress also had weakened immune responses when they received the vaccination.

Symptoms that your liver is stressed

If you’re concerned about your liver health, look out for these signs as indicators that you have a stressed liver.

  • There are changes in your skin color
  • You experience digestive problems
  • You feel aches and pains
  • You’re fatigued, even after you sleep properly or rest
  • Your urine is darker
  • You experience mood swings
  • Other symptoms that can occur are blurred vision, ringing in the ears, dizziness, insomnia, hormonal imbalances, lower sex drive, spider veins, unintentional weight loss

Tips to reduce stress, depression and have a healthy liver

If you want to protect your liver, and your health overall, it’s a good idea to reduce your level of stress. Here are some effective tips to reduce stress, depression and promote a healthy liver.

  • Tips to reduce stress, depression and have a healthy liverExercise – exercise has been shown not only to reduce stress, but promote a happier mood
  • Balance rest and activity
  • Sleep
  • Positive thinking
  • Stress reduction
  • Avoid substance use
  • Laughter and recreation
  • Good nutrition
  • Maintain a healthy weight
  • Look for warnings of toxicity on medication labels
  • Practice good hygiene to prevent infection
  • Keep hydrated to help flush out toxins
  • Don’t smoke or quit smoking
  • Manage underlying medical conditions like diabetes, hypertension or cholesterol
  • Get vaccinated for hepatitis
  • Be mindful of medication overuse
  • Minimize your salt intake
  • Reduce your alcohol consumption

Author Bio

Mohan Garikiparithi got his degree in medicine from Osmania University (University of Health Sciences). He practiced clinical medicine for over a decade before he shifted his focus to the field of health communications. During his active practice he served as the head of the Dept. of Microbiology in a diagnostic centre in India. On a three-year communications program in Germany, Mohan developed a keen interest in German Medicine (Homoeopathy), and other alternative systems of medicine. He now advocates treating different medical conditions without the use of traditional drugs. An ardent squash player, Mohan believes in the importance of fitness and wellness.


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