Decreased bone strength (osteoporosis) is commonly associated with menopausal women, which puts them at an increased risk of bone fractures—the most common cause of broken bones among the elderly. However, according to a new study, women who consume too much alcohol may be further increasing their risk of bone fractures.
Takeshi Miyamoto—an orthopedist at Keio University’s School of Medicine—and his colleagues have looked into the ALDH2 gene, which is responsible for the production of the enzyme that breaks down alcohol.
“You cannot change whether your system has a high tolerance for alcohol or not,” Miyamoto said. “But there is the possibility that you can avoid a bone fracture by taking vitamin E while becoming aware of the risks.”
The researchers discovered that people born with the ALDH2 gene not actively working have an inability to decompose acetaldehyde, which causes one to feel drunk or sick by drinking.
The research team compared the genes of 92 middle aged or elderly women who have had a hip fracture in the past to 48 women of comparable age without a history of hip fracture. The study found that the ALDH2 gene’s activity was weak in 58 percent of the women with a history of hip fracture as opposed to only 35 percent observed in the women without such history.
The study also concluded that the risk of experiencing a fracture was 2.3 times higher in those with an inactive ALDH2 gene compared to those with a functioning ALDH2 gene, after age and other factors were adjusted for.
Interestingly, when investigating the effects of acetaldehyde on mouse osteoblast cells (cells of new bone), they discovered that the cells activity became weak after the introduction of acetaldehyde—however, the gene’s activity became normal when vitamin E was supplied.