Multiple sclerosis patients can improve brain connection using video game therapy

Multiple sclerosis patients can improve brain connection using video game therapyMultiple sclerosis patients can improve brain connections using video game therapy. The researchers suggest video game therapy can help strengthen neural connections. Multiple sclerosis (MS) is a disease that affects the central nervous system. Patients may experience brain fog, muscle weakness, and difficulty thinking.

When the thalamus – a structure that works as the brain’s information hub – gets damaged, it impacts the cognitive dysfunction in multiple sclerosis.


The researchers studied the effects of video game-based cognitive rehabilitation program on the thalamus in MS patients. The program was based on a collection of games from Nintendo, which used puzzles, word memory, and other mental challenges.

Twenty-four multiple sclerosis patients with cognitive impairment were randomly assigned to either an eight-week at-home rehabilitation with 30 minutes of gaming five times a week, or to a wait list (serving as controls). The patients were evaluated with cognitive tests and by 3-Tesla resting state functional MRI (RS-fMRI) at baseline and again after the eight weeks.

Research lead Laura De Giglio said, “Functional MRI allows you to study which brain areas are simultaneously active and gives information on the participation of certain areas with specific brain circuits. When we talk about increased connectivity, we mean that these circuits have been modified, increasing the extension of areas that work simultaneously.”

At the follow-up, the participants in the video game group had significant increases in thalamic functional connectivity in brain areas corresponding to the posterior component of the default mode network that is essential for cognition.

Dr. De Giglio added, “This increased connectivity reflects the fact that video gaming experience changed the mode of operation of certain brain structures. This means that even a widespread and common use tool like video games can promote brain plasticity and can aid in cognitive rehabilitation for people with neurological diseases, such as multiple sclerosis.”

The results reveal that video game-based training is successful for cognitive abilities improvement in multiple sclerosis patients.

Improve MS by playing video games

Multiple sclerosis cognitive impairment isn’t the only symptom that can be improved through video games. Other studies have also shown that games can work to improve various symptoms. Here is a list of the six best video games for multiple sclerosis patients to improve MS-related symptoms.

Better balance – Nintendo Wii Balance Board: Lead author of the study Luca Prosperini said, “We found balance improvements after three months of training. However, the clinical benefit tends to disappear after stopping the training, probably because certain skills that are related to structural changes in the brain and are acquired or reacquired after an injury need to be kept trained constantly.” The researchers suggest anyone, not just MS patients, can benefit from the balance board.

Improved motor skills – controller-based and keyboard-based games: These games can improve hand-eye coordination along with dexterity, coordination, and strength. The researchers of the study recommend the game Counter-Strike.

Better vision – SIMS-like game: Researcher Andrew Latham said, “The key ones here are visual acuity and contrast sensitivity, but the results of training studies are mixed. While expert video game players show improved visual acuity, training [non-gamers] doesn’t seem to give that benefit. But video game training does improve contrast sensitivity. But even as adults, you can actually improve the visual acuity and attention in amblyopia patients by training with not just action video games, but also SIMS-like games.” (The SIMS imitates real life).

Improved short-term memory – action video games: Action games were shown to improve short-term memory, but had no long-term effects on memory.

Reduced chronic pain – virtual reality games: Latham explained that virtual reality games work as a distraction, so patients reduce chronic pain. Interactive games were also found to reduce pain greater than simply being distracted by TV watching.

Reduced depressive symptoms – fantasy role-playing: Choosing to be a player and explore a different world, this type of games works as psychological therapy, Latham explained. In fact, a study on fantasy role-playing games published in the British Medical Journal found these types of games were as successful at reducing depressive symptoms as cognitive behavioral therapy was.

As you can see, there is a wide variety of gaming options for different symptoms related to multiple sclerosis, the only trick is to find which games work best for you.

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Author Bio

Mohan Garikiparithi got his degree in medicine from Osmania University (University of Health Sciences). He practiced clinical medicine for over a decade before he shifted his focus to the field of health communications. During his active practice he served as the head of the Dept. of Microbiology in a diagnostic centre in India. On a three-year communications program in Germany, Mohan developed a keen interest in German Medicine (Homoeopathy), and other alternative systems of medicine. He now advocates treating different medical conditions without the use of traditional drugs. An ardent squash player, Mohan believes in the importance of fitness and wellness.


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