Understanding Jejunoileitis: Symptoms, Diagnosis, and Treatment Approaches

Understanding JejunoileitisJejunoileitis, a type of Crohn’s disease, can significantly impact an individual’s quality of life. From symptoms to diagnosis and treatment, understanding this condition is key to managing it effectively. This article provides a comprehensive guide to jejunoileitis.

What is Jejunoileitis?

Jejunoileitis is a subtype of Crohn’s disease, a form of Inflammatory Bowel Disease (IBD) that can cause chronic inflammation in any part of the gastrointestinal (GI) tract. Jejunoileitis specifically affects the jejunum and the ileum, both of which are parts of the small intestine.


Inflammation in these areas can disrupt the absorption of nutrients, potentially leading to severe discomfort and a host of symptoms. If not treated effectively, this can result in complications that could impact an individual’s health.

Symptoms of Jejunoileitis

The signs and symptoms of jejunoileitis can vary widely among individuals based on the severity and extent of the inflammation. Nevertheless, some common symptoms to watch out for include:

  • Abdominal pain: One of the hallmark symptoms of jejunoileitis is abdominal pain. This pain often presents as severe cramping and usually occurs after meals when the intestines are working to digest food.
  • Diarrhea: Individuals with jejunoileitis frequently experience diarrhea, which can sometimes contain blood or mucus due to inflammation and irritation in the intestines.
  • Weight loss: Weight loss in individuals with jejunoileitis can be due to a variety of factors, such as decreased appetite due to ongoing discomfort and malabsorption of nutrients resulting from inflammation in the small intestine.
  • Fever: Fevers are common during flare-ups of jejunoileitis. This is because the body raises its temperature in an attempt to fight off what it perceives as harmful, in this case, the inflammation in the intestines.
  • Fatigue: Fatigue in individuals with jejunoileitis can be quite significant. This can be a result of the body constantly fighting inflammation and from a lack of proper nutrient absorption due to the inflammation in the small intestine.

Recognizing these symptoms early can lead to a more prompt diagnosis and effective management of the condition.

Causes of Jejunoileitis

The exact cause of jejunoileitis isn’t fully understood, but it’s believed to be due to a combination of factors:

  • Genetic predisposition: Those with a family history of Crohn’s disease are at a higher risk.
    Immune system problems: The body’s immune system might react abnormally to normal gut bacteria, causing inflammation.
  • Environmental factors: Certain lifestyle choices, such as smoking or consuming a diet high in fat and low in fruits and vegetables, can increase the risk of developing jejunoileitis.

Diagnosis of Jejunoileitis

Diagnosis is based on a combination of clinical assessment, imaging, and laboratory testing:

  • Physical exam and history: Doctors will take a detailed medical history and perform a physical examination.
  • Blood tests: These can show signs of inflammation or anemia, a common complication of jejunoileitis.
  • Imaging studies: Including CT scans or MRIs, these can provide detailed images of the small intestine.
  • Endoscopy: A flexible tube with a camera at the end is inserted down the throat to examine the small intestine.
  • Biopsy: A small tissue sample may be taken during an endoscopy to be analyzed in a lab.

Treatment Approaches for Jejunoileitis

The primary goal in treating jejunoileitis is to reduce inflammation, alleviate symptoms, and improve the quality of life. An individual’s treatment plan may vary based on the severity of symptoms, overall health, and specific needs. Here’s a more detailed look into the common treatment approaches for jejunoileitis:


Medications play a crucial role in the management of jejunoileitis. They can be used to reduce inflammation, control symptoms, and maintain remission.

  • Anti-inflammatory drugs: These medications, such as aminosalicylates and corticosteroids, are often the first step in treating jejunoileitis. They help reduce inflammation in your gut, alleviating symptoms like pain and diarrhea.
  • Immune system suppressors: These drugs, including azathioprine, methotrexate, and cyclosporine, reduce inflammation by taming the immune response. This approach can be very effective for patients with moderate to severe jejunoileitis.
  • Antibiotics: Certain antibiotics can be beneficial in treating jejunoileitis, especially when complications such as fistulas or abscesses are present.

It’s essential to remember that all medications should be taken strictly as prescribed by your doctor, as each comes with potential side effects and risks. Never alter your dosage or stop taking your medication without consulting your healthcare provider.

Nutritional Therapy

Nutritional therapy is often a key part of treating jejunoileitis, as the inflammation can make it hard for your body to absorb nutrients.

  • High-nutrient, low-fiber diet: Eating foods high in nutrients but low in fiber can help provide necessary nutrition without aggravating symptoms. Foods like lean proteins (chicken, fish), well-cooked fruits and vegetables, and refined grains are typically well-tolerated.
  • Enteral nutrition: In severe cases, a special liquid diet, or enteral nutrition, might be recommended. This diet allows the bowel to rest and heal while providing all the necessary nutrients.

Remember, individual dietary needs can vary greatly, so working with a dietitian or nutritionist experienced in treating inflammatory bowel disease is essential.


In some cases, if medication isn’t effective or if complications occur, surgery might be required. This usually involves removing the damaged portions of the intestine. Surgery is considered a last resort and is typically reserved for those with severe symptoms that significantly impact quality of life.

In conclusion, treating jejunoileitis involves a combination of medication, nutritional therapy, and, in severe cases, surgery. The goal is to reduce inflammation, manage symptoms, and prevent complications. As always, it’s vital to work closely with your healthcare provider to find the best treatment approach for you.

What are the Complications of Jejunoileitis?

Jejunoileitis, like other forms of inflammatory bowel disease, can lead to several complications if left untreated or not adequately managed. Understanding these potential issues is critical to recognizing the importance of a proper treatment plan. Here are some possible complications:

Intestinal Obstruction

Intestinal obstruction is a serious complication where the intestine becomes narrowed due to prolonged inflammation. This chronic inflammation can lead to scarring and the formation of strictures, which are thickened, narrowed sections of the intestine. These strictures can interfere with the normal movement of food and waste through the intestines, leading to blockages.

Symptoms of an intestinal obstruction can include severe abdominal pain, bloating, constipation, and vomiting. This is a medical emergency that requires immediate treatment, which may include surgery to remove the obstruction.


Inflammation from jejunoileitis can impair the body’s ability to digest food and absorb nutrients, leading to malnutrition. This is particularly problematic because the jejunum and ileum—the parts of the small intestine affected by jejunoileitis—are vital for nutrient absorption.

Malnutrition can manifest in several ways, including unexplained weight loss, fatigue, and a general sense of weakness. Over time, it can lead to deficiencies in vital vitamins and minerals, negatively affecting overall health. It can also exacerbate symptoms of jejunoileitis, creating a vicious cycle of inflammation and poor nutrient absorption.


Fistulas are abnormal connections or passageways that develop between different parts of the intestine or between the intestine and other organs, such as the bladder or skin. They are a result of severe inflammation that extends through the entire thickness of the bowel wall.


These abnormal connections can cause partially digested food to bypass areas of the intestine that are important for absorption. Fistulas can also lead to persistent infections or abscesses, as bacteria from the gut can spread to other parts of the body. Symptoms of fistulas can include pain, fever, and leakage of intestinal contents.

When to See a Doctor

It’s essential to see a doctor if you’re experiencing symptoms like persistent diarrhea, abdominal pain, unexplained weight loss, or fatigue. Early diagnosis and treatment can help manage symptoms and prevent complications.

In conclusion, while jejunoileitis is a serious condition, understanding its symptoms, causes, and treatment options can help those affected manage their condition effectively and lead a healthy life. As always, it is important to consult with a healthcare professional if you suspect you might have jejunoileitis.

Author Bio

Devon Andre has been involved in the health and dietary supplement industry for a number of years. Devon has written extensively for Bel Marra Health. He has a Bachelor of Forensic Science from the University of Windsor, and went on to complete a Juris Doctor from the University of Pittsburgh. Devon is keenly aware of trends and new developments in the area of health and wellness. He embraces an active lifestyle combining diet, exercise and healthy choices. By working to inform readers of the options available to them, he hopes to improve their health and quality of life.