Role of Exercise to Protect against Fatty Liver Associated Diseases

Exercise can play a great role in preventing the development of fatty liver disease. A new study from the German Center for diabetes research (DZD) has shown which molecular adaptations of the liver mitochondria are observed during exercise.

Some mice were fed a high-energy diet for this study, while others received regular treadmill training. After following the upper six weeks, researchers examined the animal’s livers and muscle strength for changes in the transcriptome, the mitochondrial proteome, lipid composition, and mitochondrial function.


They found that exercising regulated important enzymes of fructose and glucose degradation in the liver as well as the mitochondrial pyruvate metabolism.

Overall, this process helps less fat to be stored in the liver, and specific lipids such as diacylglycerol species are lowered. In the exercised mice, glucose control was also improved, and an increased respiratory capacity of the skeletal muscles relieved metabolic stress in the liver.

Prof. Dr. Cora Weigert said, “This shows that regular physical activity regulates many targets at the same time as key notes of metabolic pathways, an effect that cannot be achieved with monotherapy.”

About Non-Alcoholic Fatty Liver Disease

One in four people suffers from non-alcoholic liver disease (NAFLD), also known as metabolic liver disease (MAFLD). Of those affected, patients often also have type 2 diabetes as well as an increased risk of liver cirrhosis and cardiovascular disease. This condition is also widely associated with increased mortality.

NAFLD is believed to be due to an imbalance between energy intake and consumption. This imbalance leads to fat deposits in the liver and can impair the function of the mitochondria over time. These are both risk factors for developing hepatic insulin resistance and liver inflammation.

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Author Bio

Sarah began her interest in nutritional healing at an early age. After going through health problems and becoming frustrated with the conventional ways doctors wanted to treat her illness (which were not working), she took it upon herself to find alternative treatments. This led her to revolutionize her own diet to help her get healthier and tackle her health problems. She began treating her illness by living a more balanced lifestyle through healthy food choices, exercise and other alternative medicine such as meditation. This total positive lifestyle change led her to earn a diploma in Nutritional Therapy from Health Sciences Academy in London, England. Today, Sarah enjoys helping others by teaching healthy lifestyle changes through her personal consultations and with her regular contributions to the Doctors Health Press. Also, passionate about following her dreams in life, Sarah moved to France and lived in Paris for over 5 years where she earned a certification in beadwork and embroidery from Lesage (an atelier owned by Chanel). She then went on to be a familiar face sitting front row and reporting from Paris Fashion Week. Sarah continues to practice some of the cultural ways of life she learned while in Europe. They enjoy their food, and take the time to relax and enjoy many of life’s little moments. These are life lessons she is glad to have brought back home with her.


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