Multiple Depressive Symptoms Have an Increased Risk for Stroke: Study

Worried man sitting on bed with hand on forehead in bedroom in serious mood emotion. Major Depressive Disorder called MDD concept. Lonely symptom of men alertness. Physical healthcare and social issuePeople who suffer from multiple depressive symptoms have an increased risk for stroke, according to a study published in Neurology: Clinical Practice. Researchers found that individuals who scored higher on a test designed to measure depressive symptoms had a higher stroke risk than those with lower scores.

The study led by investigators at the University of Alabama at Birmingham and the University of Alabama involved 9,529 black and 14,516 white, stroke-free participants. Each participant was 45 years and older and enrolled in the UAB-led REGARDS study. The REGARDS study is a national, population-based longitudinal study designed to examine the relationship between stroke incidence, mortality, and risk factors associated with racial and regional disparities.


To assess depressive symptoms in participants, researchers used the four-item version of the Center for Epidemiologic Studies Depression Scale, known as CES-D-4. This scale helps to evaluate depressive symptoms and assess how often respondents felt depressed, sad, lonely, or had crying spells.

Over the follow-up of nine years, there were 1,262 incidents of stroke among the participants. After demographic adjustments, researchers found that compared to participants with no depressive symptoms, participants with CES-D-4 scores of one to three had a 39 percent increased stroke risk. Participants with CES-D-4 scores of more than four experienced a 54 percent higher risk of stroke, and there was no evidence of a differential effect by race.

Senior author of the study, Virginia Howard, Ph.D., said, “There are a number of well-known risk factors for strokes, such as high blood pressure, diabetes and heart disease; but we are beginning to understand that there are non-traditional risk factors as well, and having depressive symptoms looms high on that list. These non-traditional risk factors need to be in the conversation about stroke prevention.”

Depressive Symptoms in Black Population

This study helps medical professionals to recognize stroke risk from patients who exhibit depressive factors. It also set out to determine whether symptoms might help explain the increased risk that the black population has for stroke, especially in the southern United States.


Previously, research has not been able to identify why there is a difference in stroke risk between races. As traditional risk factors have not been able to identify a factor, this study had hoped to find an association between depressive symptoms and stroke. Depression often goes undetected and undiagnosed in black patients. They are also frequently less likely to receive adequate care and management for mental health.

Physicians typically care for particular conditions such as hypertension, diabetes, or stroke, and this study opens the discussion for considering non-traditional risk factors. One such element should be screening for mental health.

As this study was unable to find a substantial relationship between depressive symptoms and stroke risk in the black population, further research is needed to explore non-traditional risk factors for stroke. It is essential to understand the difference in both populations’ risk factors, so health care providers can offer treatments accordingly.

Author Bio

About eight years ago, Mat Lecompte had an epiphany. He’d been ignoring his health and suddenly realized he needed to do something about it. Since then, through hard work, determination and plenty of education, he has transformed his life. He’s changed his body composition by learning the ins and outs of nutrition, exercise, and fitness and wants to share his knowledge with you. Starting as a journalist over 10 years ago, Mat has not only honed his belief system and approach with practical experience, but he has also worked closely with nutritionists, dieticians, athletes, and fitness professionals. He embraces natural healing methods and believes that diet, exercise and willpower are the foundation of a healthy, happy, and drug-free existence.


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