Midlife Factors That Boost Alzheimer’s Risk

New research suggests that the three biggest lifestyle factors that boost the odds of dementia are obesity in middle age, inactivity, and the lack of a high school diploma.

That’s a shift from what they were in 2011 when the most important modifiable risk factors were physical inactivity, depression, and smoking.


The study also found that the top three risk factors are not one size fits all and that the leading modifiable risk factors vary slightly based on race and ethnicity. Obesity was the number one factor amongst white, Black, and Native American adults. Lack of exercise was the top threat to Asian Americans, while the number one risk factor for Latin Americas was low education.

Of course, not every risk factor for Alzheimer’s and dementia is modifiable. Age remains the biggest factor, while genetics play another. People carrying a gene variant called APOE4 have a greater chance of getting the disease.

That said, it is estimated that 40 percent of dementia cases worldwide can be attributed to modifiable risk factors.

Along with the top three, factors like high blood pressure, diabetes, heavy drinking, and hearing loss played a role.

The findings were published in JAMA Neurology.


So, why these risk factors? Obesity, a lack of activity, diabetes, and smoking all damage blood vessels that feed the brain. It’s linked to heart health, and as plenty of studies have previously established, what’s good for the heart is good for the brain.

Education levels can be a little harder to determine. Experts believe that it may have something to do with a theory called “cognitive reserve.” It’s based on the idea that people with more education might be better equipped to hold off the pathological brain changes seen in dementia and maintain thinking and memory for a longer time.

It’s good to know these modifiable factors and how they can impact you so you can make the necessary adjustments to give yourself the best shot at avoiding dementia.

Author Bio

About eight years ago, Mat Lecompte had an epiphany. He’d been ignoring his health and suddenly realized he needed to do something about it. Since then, through hard work, determination and plenty of education, he has transformed his life. He’s changed his body composition by learning the ins and outs of nutrition, exercise, and fitness and wants to share his knowledge with you. Starting as a journalist over 10 years ago, Mat has not only honed his belief system and approach with practical experience, but he has also worked closely with nutritionists, dieticians, athletes, and fitness professionals. He embraces natural healing methods and believes that diet, exercise and willpower are the foundation of a healthy, happy, and drug-free existence.