Middle-Aged Muscle Mass Tied to Heart Disease Risk in Later Life

Maintaining muscle mass in middle age could be an effective way of warding off heart disease. According to new research published in the journal Epidemiology & Community Health, the amount of lean muscle mass that a healthy person has in middle age is linked to their future risk of cardiovascular health, at least in men.

Previous studies have shown that muscle mass is associated with cardiovascular events, but these have focused primarily on the health outcomes of patients with existing heart disease. This is why researchers set out to find if muscle mass in middle age might also make a difference in people without heart disease.


For the study, researchers monitored 2,020 people and analyzed the number of new cases of cardiovascular disease occurring over 10 years. Participants had an average age of 45, and none had heart disease at the start of the study. They all provided lifestyle information including their daily level of physical activity and how closely they followed a Mediterranean diet.

Circulating blood fat levels were measured along with indicators of inflammation. Blood pressure and weight (BMI) were also monitored as they are all potential risk factors for heart disease. Muscle mass was calculated using previously published data, which was adjusted for height and weight.

Over ten years of the study, 272 participants experienced fatal and non-fatal cases of cardiovascular disease, including stroke and minor stroke. It was found that men were around four times as likely to develop cardiovascular disease as women, and muscle mass was associated with cardiovascular disease risk.

It was concluded that the fewest cases of cardiovascular disease occurred in the people with the highest muscle volume. Those who had the highest muscle tissue volume were 81% less likely to have a cardiovascular event such as a heart attack or stroke. It was also shown that all risk factors for cardiovascular disease such as inflammation, high blood pressure, diabetes, and obesity were all lower among those with high muscle volume.

The participants with the highest muscle volume tended to be younger, male, smokers, and those who were physically active and who mostly consumed a Mediterranean-style diet. Researchers caution that the gender disparity may be partly due to higher muscle volume in men due to hormonal differences between the sexes in the aging process.

Muscle Volume Decreases with Age


Muscle tissue volume starts to progressively decrease from the mid-30s onwards at a rate of around 3% every decade. It has been shown to play an active role in various metabolic processes, and its decline is associated with health issues such as disability and a heightened risk of death.

Researchers concluded the study, saying, “This is an observational study, and as such, can’t establish cause. Nevertheless, the results “point to the importance of [skeletal muscle mass] preservation in relation to [cardiovascular disease] risk.”

They suggest along with many health professionals that physical activity, including resistance training, can help to preserve lean muscle mass. A diet rich in protein may also help in the aging process and can keep muscle mass at a higher level, therefore cutting risk of cardiovascular events.

Author Bio

About eight years ago, Mat Lecompte had an epiphany. He’d been ignoring his health and suddenly realized he needed to do something about it. Since then, through hard work, determination and plenty of education, he has transformed his life. He’s changed his body composition by learning the ins and outs of nutrition, exercise, and fitness and wants to share his knowledge with you. Starting as a journalist over 10 years ago, Mat has not only honed his belief system and approach with practical experience, but he has also worked closely with nutritionists, dieticians, athletes, and fitness professionals. He embraces natural healing methods and believes that diet, exercise and willpower are the foundation of a healthy, happy, and drug-free existence.