Iron Deficiency in Middle Age Is Associated with a Higher Risk of Heart Diseases

Healthy product sources of Fe. Top view, food background, iron ingredients: buckwheat, dried fruit, apple, eggs on a white background.Some cases of heart disease could be avoided by preventing iron deficiency, according to a new study. The research published in the ESC Heart Failure journal suggests growing evidence of a link between an iron deficiency in middle age and heart disease.

Previous studies had found that patients with cardiovascular diseases such as heart failure had worse outcomes when there was an iron deficiency. In patients with heart failure, treatments with intravenous iron improved patients’ symptoms, functional capacity, and quality of life.


Patients for this research were all enrolled in the FAIR-HF2 trial, which investigated the impact of intravenous iron supplementation on the risk of death in patients with heart failure.

Current Study

This current study looked at the association between iron deficiency and heart diseases in the general population. It included 12,164 participants from three European population-based cohorts.

The median age of participants was 59 years, and 55% were women. At the beginning of the study, lifestyle and medical issues were assessed through a thorough clinical assessment, including cholesterol, high blood pressure, diabetes, and smoking.

All participants were classified with either absolute iron deficiency, which includes store iron (ferritin), or functional iron deficiency, which includes iron in storage (ferritin) and iron in circulation for use by the body (transferrin).

The author of the study, Dr. Schrage, explained: “Absolute iron deficiency is the traditional way of assessing iron status, but it misses circulating iron. The functional definition is more accurate as it includes both measures and picks up those with sufficient stores but not enough in circulation for the body to work properly.”

Participants were followed up for coronary heart disease and stroke, death due to cardiovascular diseases, and all-cause death. After adjusting for lifestyle behaviors and illness, researchers analyzed the association between iron deficiency and health outcomes.

Researchers found that during a follow-up of 13.3 years, there were 2,212 deaths. Of these, a total of 573 participants died from a cardiovascular cause.

Functional iron deficiency was associated with a 24% higher risk of coronary heart disease, 26% raised risk of cardiovascular mortality, and 12% increased risk of all-cause mortality compared to those who did have functional iron deficiency.


Absolute iron deficiency was associated with a 20% raised risk of coronary heart disease compared to those who did not have the condition. It was also not linked with mortality. There were also no associations between iron status and incident stroke.

“This analysis suggests that if iron deficiency had been absent at baseline, about 5% of deaths, 12% of cardiovascular deaths, and 11% of new coronary heart disease diagnoses would not have occurred in the following decade,” said Dr. Schrage.

It was noted that future studies should examine the associations in younger and non-European cohorts. They should also focus on randomized trials investigating the effect of treating iron deficiency in the general population.

Author Bio

Sarah began her interest in nutritional healing at an early age. After going through health problems and becoming frustrated with the conventional ways doctors wanted to treat her illness (which were not working), she took it upon herself to find alternative treatments. This led her to revolutionize her own diet to help her get healthier and tackle her health problems. She began treating her illness by living a more balanced lifestyle through healthy food choices, exercise and other alternative medicine such as meditation. This total positive lifestyle change led her to earn a diploma in Nutritional Therapy from Health Sciences Academy in London, England. Today, Sarah enjoys helping others by teaching healthy lifestyle changes through her personal consultations and with her regular contributions to the Doctors Health Press. Also, passionate about following her dreams in life, Sarah moved to France and lived in Paris for over 5 years where she earned a certification in beadwork and embroidery from Lesage (an atelier owned by Chanel). She then went on to be a familiar face sitting front row and reporting from Paris Fashion Week. Sarah continues to practice some of the cultural ways of life she learned while in Europe. They enjoy their food, and take the time to relax and enjoy many of life’s little moments. These are life lessons she is glad to have brought back home with her.