Dementia Risk Lowers in Old Age for People in Mentally Stimulating Job: Study

Happy relaxed young woman sitting in her kitchen with a laptop in front of her stretching her arms above her head and looking out of the window with a smileAccording to a new study from The BMJ, people who have mentally stimulating jobs have a lower risk of dementia as they age. The relationship between dementia and a job that someone holds is believed to be due to lower levels of specific proteins that may prevent brain cells from forming new connections.

Previous research has shown that cognitive stimulation can prevent or postpone dementia. However, recent long-term studies have suggested that leisure time cognitive activity does not reduce the risk of dementia, but workplace exposure may.


Still, no studies have been able to produce compelling evidence of the benefit of cognitive stimulation at work. This is what led a team of international researchers to examine and identify protein pathways for this association.

The International Study

For the study, three associations were examined. This first was cognitive stimulation and dementia risk in 107,896 participants. The second was cognitive stimulation and proteins in a random sample of 2,261 participants. Thirdly, proteins and dementia risk in 13,656 participants from two studies were studied.

At the start of the study, cognitive stimulation at work was measured, and participants were tracked for an average of 17 years. These findings were based on studies from the United Kingdom, the United States, and Europe, which looked at relationships between work-related factors and chronic diseases, disability, and mortality.

After adjusting for potentially influential factors such as age, sex, education, and lifestyle choices, the risk of dementia was found to be lower for participants with high to low mentally stimulating jobs. Cognitive stimulation was associated with lower levels of three proteins linked to cognitive stimulation and dementia. This helps researchers to provide possible clues to underlying biological mechanisms.


This association did not differ between men and women or according to age, but there was an indication that the association was stronger for Alzheimer’s disease than for other dementias. The findings remained even after further adjustments for various established dementia risks, including diabetes, coronary heart disease, and stroke.

“The findings that cognitive stimulation is associated with lower levels of plasma proteins that potentially inhibit axonogenesis and synaptogenesis and increase the risk of dementia might provide clues to underlying biological mechanisms,” researchers concluded.

This study is a reminder that more extensive, population-based studies are needed to understand the complex relationships between dementia and cognitive stimulation. With an aging population and a rise in dementia, it is vital to continue the work that has so far remained unclear.

Author Bio

Sarah began her interest in nutritional healing at an early age. After going through health problems and becoming frustrated with the conventional ways doctors wanted to treat her illness (which were not working), she took it upon herself to find alternative treatments. This led her to revolutionize her own diet to help her get healthier and tackle her health problems. She began treating her illness by living a more balanced lifestyle through healthy food choices, exercise and other alternative medicine such as meditation. This total positive lifestyle change led her to earn a diploma in Nutritional Therapy from Health Sciences Academy in London, England. Today, Sarah enjoys helping others by teaching healthy lifestyle changes through her personal consultations and with her regular contributions to the Doctors Health Press. Also, passionate about following her dreams in life, Sarah moved to France and lived in Paris for over 5 years where she earned a certification in beadwork and embroidery from Lesage (an atelier owned by Chanel). She then went on to be a familiar face sitting front row and reporting from Paris Fashion Week. Sarah continues to practice some of the cultural ways of life she learned while in Europe. They enjoy their food, and take the time to relax and enjoy many of life’s little moments. These are life lessons she is glad to have brought back home with her.