Complete symptom resolution for depression reduces recurrence: Study

Complete symptom resolution for depression reduces recurrence: StudyResearchers have found that complete symptom resolution for a person with depression can greatly reduce the recurrence of another major depressive episode. The findings, which come from researchers at the University of California, San Diego School of Medicine, uncovered that in comparison to partial resolution, complete resolution of symptoms reduces recurrence of depression. The findings reveal that there is a strong need to clinically redefine what the end of major depressive episodes truly means. Changes in the management of depression treatment, too, need to be conducted.

First author, Lewis L. Judd, M.D., said the end of major depressive episodes is currently defined as eight weeks with “no more than minimal” residual symptoms. The definition includes two levels of depressive symptom resolution: Asymptomatic recovery (no depressive symptoms) and residual symptom resolution (some mild continued symptoms). The researchers compared the two levels in regards to their likeliness of resulting in future depressive episodes.


Data was analyzed from 322 patients with major depressive episodes who were followed for up to 31 years. 62.1 percent of patients recovered asymptomatically. Dr. Judd added that this group remained depression-episode free for 4.2 times longer than those who still had residual symptoms.

Residual symptoms were three times as likely to increase the return of major depressive episodes within one year. The residual symptom group also experienced greater depressive illness burden in the following 10 to 20 years – they had greater difficulties with household chores and personal relationships.

Dr. Judd suggests that treatment for depressive symptoms should continue until all symptoms are completely resolved. He added, “If you treat a major depressive episode until there are no remaining symptoms, the individual is likely to enter a stable state of wellness and be free of depression for months or even years. As long as they have any residual symptoms, they are still ill and at high risk for relapse.”

Dr. Judd says the findings suggest, for the first time, the end of major depressive episodes in terms of symptoms and necessary duration. For the asymptomatic period necessary to define the end of major depressive episodes, the researchers suggest four consecutive weeks defines recovery.

The findings were published in Journal of Clinical Psychiatry.


Author Bio

Emily Lunardo studied medical sociology at York University with a strong focus on the social determinants of health and mental illness. She is a registered Zumba instructor, as well as a Canfit Pro trainer, who teaches fitness classes on a weekly basis. Emily practices healthy habits in her own life as well as helps others with their own personal health goals. Emily joined Bel Marra Health as a health writer in 2013.