A New Drug May Change Life for People Suffering with Celiac Disease

Sales Assistant In Bakery Putting Gluten Free Label Into Freshly Baked Savoury RollThere are not many ways to treat Celiac disease. For many, averting flare-ups involves a degree of luck or following a rigid diet.

But an experimental drug is showing some promise, and it may have the potential to create a revolutionary change in celiac treatment.


Findings from a new trial suggest the drug may prevent intestinal damage caused by the disease.

Celiac disease is a condition where the immune system attacks the lining of the intestine when a genetically susceptible person eats gluten. Gluten is a protein found in wheat, rye, and barley.

Symptoms of the condition include diarrhea, extreme abdominal pain, fatigue, and weight loss. But it also damages hair-like structures in the intestinal lining called villi. Villi absorb nutrients from food, so people with celiac develop a higher risk for malnourishment and further condition like anemia and thinning bones.

The current treatment for celiac disease is avoiding traces of gluten in the diet. It is very difficult to maintain and a struggle for many.

The experimental drug, called ZED1227, inhibits the role of an intestinal enzyme that plays a key role in celiac’s autoimmune response.

To test it, the drugmaker enrolled 163 adults with celiac disease who had been successful using a gluten-free diet for at least one year. They were randomly assigned to one of four groups: three were given the drug to take every morning for six weeks, and the other was given a placebo.

Participants were instructed to eat a biscuit with a moderate amount of gluten thirty minutes after taking the pill.


After six weeks, the trial found that patients on any dose of the drug showed fewer signs of intestinal damage versus the placebo group. About 8 percent of participants on the highest dose experienced a minor skin rash as a side effect.

Larger studies are needed to see if the drug can adequately block other celiac symptoms, and even if does and goes into large scale production, it will likely not fully replace current treatments.

It would likely, however, be a complimentary piece to help limit intestinal damage caused by the disease.

Author Bio

About eight years ago, Mat Lecompte had an epiphany. He’d been ignoring his health and suddenly realized he needed to do something about it. Since then, through hard work, determination and plenty of education, he has transformed his life. He’s changed his body composition by learning the ins and outs of nutrition, exercise, and fitness and wants to share his knowledge with you. Starting as a journalist over 10 years ago, Mat has not only honed his belief system and approach with practical experience, but he has also worked closely with nutritionists, dieticians, athletes, and fitness professionals. He embraces natural healing methods and believes that diet, exercise and willpower are the foundation of a healthy, happy, and drug-free existence.