Testosterone replacement therapy does not increase heart attack or stroke risk, study

Testosterone replacement therapy does not increase heart attack or stroke riskA recent study uncovered that generally healthy men who undergo testosterone replacement therapy do not become more prone to getting a heart attack or stroke. The findings come from researchers at Intermountain Medical Center Heart Institute in Salt Lake city who looked at 1,472 men aged 52 and 63 all with low testosterone levels but no prior history of heart disease. The researchers found that overall healthy men who achieved normal testosterone levels through therapy did not have a higher risk of heart disease, stroke, or death.

Co-director of the research Dr. Brent Muhlestein said, “Our research examined the potential cardiovascular risks associated with generally healthy men who use testosterone supplements to normalize their levels and found no increase in those risk factors. In fact, testosterone therapy in this population was shown to reduce the risk of heart attack, stroke, and death, when compared to those men who weren’t taking testosterone supplementation.”


Earlier, the FDA implemented that testosterone therapies be labeled to reveal a possible increased risk of heart attack or stroke. The FDA has reported that testosterone therapy use has grown among older men from 1.9 million men in 2009 to 2.3 million men in 2013.

Dr. Muhlestein added, “This particular study provides assurances to physicians and patients that using testosterone replacement therapy in a generally healthy population of men over the age of 50 to normalize levels doesn’t increase a patient’s risk of a heart attack or stroke, and actually shows a reduction in those risks.”

Testosterone therapy does not increase heart attack risk in men: Previous study

A previous study also found that testosterone therapy does not increase the risk of heart attack in men. For that study, over 25,000 older men on testosterone therapy were examined.

The study, conducted by researchers at University of Texas Medical Branch at Galveston, looked at 25,420 men over the age of 66 who were treated with testosterone therapy for up to eight years. Lead author of the study Jacques Baillargeon said, “Our investigation was motivated by a growing concern, in the U.S. and internationally, that testosterone therapy increases men’s risk for cardiovascular disease, specifically heart attack and stroke. This concern has increased in the last few years based on the results of a clinical trial and two observational studies,” he said. “It is important to note, however, that there is a large body of evidence that is consistent with our finding of no increased risk of heart attack associated with testosterone use.”

Not only did the findings of the study reveal that men on testosterone therapy did not have an increased risk of heart attack, but that even men with a higher probability of cardiovascular disease also experienced a lower risk of heart attack in comparison to men of same age not using testosterone therapy.

Baillargeon concluded, “This is a rigorous analysis of a large number of patients. Our findings did not show an increased risk of heart attack associated with testosterone use in older men,” he said. “However, large–scale, randomized clinical trials will provide more definitive evidence regarding these risks in the coming years.”

Author Bio

Mohan Garikiparithi got his degree in medicine from Osmania University (University of Health Sciences). He practiced clinical medicine for over a decade before he shifted his focus to the field of health communications. During his active practice he served as the head of the Dept. of Microbiology in a diagnostic centre in India. On a three-year communications program in Germany, Mohan developed a keen interest in German Medicine (Homoeopathy), and other alternative systems of medicine. He now advocates treating different medical conditions without the use of traditional drugs. An ardent squash player, Mohan believes in the importance of fitness and wellness.



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