Role of hunger hormone leptin in obesity related cardiovascular disease

Obese women with heart failure live longer than obese men

Mildly obese women live slightly longer than mildly obese men when they have heart failure, according to new findings. Further findings suggest these heavier women may also outlive their normal-weight female counterparts with heart failure as well.

Co-author Dr. Carl Lavie said, “It is not doomsday when an overweight or mildly obese patient, especially female, develops heart failure, as the prognosis may be quite good. There is an ‘obesity paradox’ in heart failure. Despite the adverse effects that overweight and obesity have on heart disease risk and on heart function, many studies, including several of my own, show that overweight and at least mildly obese patients with heart failure have a better short-term prognosis than do lean heart failure patients.”

The research examined 4,000 individuals with heart failure. The American Heart Association estimates 5.7 million Americans suffer from the condition where the heart does not pump blood like it should.

Lead researcher, Dr. Leslie Cho, agrees the fat paradox appears to exist as the research shows that obese individuals should lose weight to keep their heart healthy, but women who are overweight don’t need to achieve the ideal, normal bodyweight to live longer with the condition.

Cho does caution that the findings only reveal an association and not that being overweight extends women’s lives with heart failure.

During the study researchers first observed an advantage for men, but that soon disappeared when factors like smoking, diabetes and medications were taken into account. Compared to normal-weight males, being overweight or obese shorted the lives of men with heart failure.

Women with the longest survival rates had a body mass index (BMI) between 25 and 29.9. A BMI over 40 added no benefits to longevity.

Lavie concluded, “Improving physical activity and fitness should be emphasized to prevent heart failure and improve its prognosis.”

The findings were published in JACC: Heart Failure.

Also Read: Heart disease risk factor, heart aging, differs in men and women



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