Heart disease risk in men linked to high testosterone and low estrogen

Heart disease risk in men linked to high testosterone and low estrogenHeart disease risk in men is linked to higher testosterone levels and lower estrogen levels. Men often have higher incidences of heart disease than premenopausal women, but for a long time the reason behind it was not really understood. A study has found that testosterone and estrogen may play key roles in heart disease, especially in relation to its increased risk in men.

Men have higher testosterone levels and lower estrogen levels compared to premenopausal women. Doctors suggest that estrogen protects against heart disease, whereas testosterone may promote it.


The study, which included 400 healthy men, has found that high testosterone levels contributed to a reduction in HDL (good) cholesterol levels, while estrogen levels did not reveal this association. Low levels of estrogen, on the other hand, contributed to higher fasting glucose levels, worsening insulin resistance, and increasing fat in the muscle – these are signs of diabetes, which in turn can lead to heart disease, too.

The researchers compared two groups of men whose hormone levels were temporarily altered with medication to help determine which hormone played a larger role in cardiovascular disease.

One group had their estrogen levels lowered, and the other received either a placebo or testosterone suppressants.

The researchers found that higher testosterone and lower estrogen were associated with worsened cardiovascular risk factors, such as increasing bad cholesterol.

Heart disease facts and risk factors in men

Heart disease is the leading cause of death among men in America, accounting for one in every four deaths. Additionally, heart disease is the leading cause of death among racial groups and minorities. Roughly 8.5 percent of whites, 7.9 percent of blacks, and 6.3 percent of Hispanics have coronary heart disease.


Nearly half of men who die from sudden heart disease do not present any symptoms. However, lack of symptoms does not mean your risk is smaller. Lastly, nearly 70 to 80 percent of sudden cardiac events occur in men.

Risk factors for heart disease in men include:

  • Diabetes
  • Being overweight or obese
  • Unhealthy diet
  • Lack of physical activity
  • Excessive alcohol use
  • Smoking
  • High blood pressure
  • High cholesterol

By controlling, managing, and lowering your risk factors you can better protect yourself against heart disease.

Author Bio

Mohan Garikiparithi got his degree in medicine from Osmania University (University of Health Sciences). He practiced clinical medicine for over a decade before he shifted his focus to the field of health communications. During his active practice he served as the head of the Dept. of Microbiology in a diagnostic centre in India. On a three-year communications program in Germany, Mohan developed a keen interest in German Medicine (Homoeopathy), and other alternative systems of medicine. He now advocates treating different medical conditions without the use of traditional drugs. An ardent squash player, Mohan believes in the importance of fitness and wellness.



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