Alzheimer’s disease progress influenced by brain-blood barrier disruption

Alzheimer’s disease progress influenced by brain-blood barrier disruptionAs researchers continue to explore Alzheimer’s disease, they note that the immune system and disruptions in the brain-blood barrier can lead to its progression. The important brain-blood barrier is called the blood-cerebrospinal fluid (CSF) and, unfortunately, it is often neglected. Disruptions in the blood-CSF can negatively impact the progression of Alzheimer’s disease, but on the other hand, it may be blocked by a matrix metalloproteinase (MMP) inhibitor.

Roosmarijn Vandenbroucke from the Claude Libert Group said, “Although further research is needed, these data suggest that blocking MMP activity or upstream inflammatory signaling, might have therapeutic potential to treat Alzheimer’s disease. It is important we could demonstrate the role of the blood-cerebrospinal fluid barrier, because this would be an easier target to reach in comparison with the targets of current therapies.”


In Alzheimer’s disease the brain-blood barrier crumbles, but little is known as to how or why this occurs. The study sheds some light as to why this occurs.


Author Bio

Devon Andre has been involved in the health and dietary supplement industry for a number of years. Devon has written extensively for Bel Marra Health. He has a Bachelor of Forensic Science from the University of Windsor, and went on to complete a Juris Doctor from the University of Pittsburgh. Devon is keenly aware of trends and new developments in the area of health and wellness. He embraces an active lifestyle combining diet, exercise and healthy choices. By working to inform readers of the options available to them, he hopes to improve their health and quality of life.