Pulmonary Hypertension Increases with Decreasing Kidney Function Associated with CKD

Written by Mohan Garikiparithi
Published on

Pulmonary Hypertension Increases...

Pulmonary hypertension has had relatively little research done on it until recently. It’s a rare condition that has been established as a complication of chronic kidney disease (CKD). The condition is associated with a high mortality rate.

It’s a progressive disease, increasing pulmonary vascular resistance (PVR) and pulmonary arterial pressure (PAP) the longer the illness remains active. The condition can be induced by disorders of the left ventricle or by CKD.

The researchers examined the data of 705 patients with chronic kidney disease for over two years. The prevalence of pulmonary hypertension was the main focus of the investigation.

Patients were excluded from the study if they had a connective tissue disease aside from lupus, HIV, congenital heart disease, acute heart failure, portal hypertension and pulmonary veno-occlusive disease, interstitial lung disease, sleep apnea, or the obstruction of pulmonary arterial vessels by thromboemboli, tumors, or foreign bodies.

Overall, nearly half of the CKD patients exhibited pulmonary hypertension. It was also noted that the percentage of patients with pulmonary hypertension increased as kidney function continued to decrease.

Higher-Stage CKD Patients More Likely to Have Pulmonary Hypertension

For participants with stage five CKD, 64 percent also exhibited signs of pulmonary hypertension. Stage one patients showed a 14 percent likelihood to have pulmonary hypertension. This increases drastically by stage two, with 33 percent of patients experiencing pulmonary hypertension. Stages three and four showed 38 percent and 40 percent of patients managing pulmonary hypertension on top of their CKD, respectively.

The prevalence of pulmonary hypertension was also seemingly related to the patients’ dialysis status. The patients in dialysis showed a higher likelihood of having pulmonary hypertension.

Other risk factors included body mass index, hemoglobin, triglyceride, proteinuria, parathyroid hormone, and estimated glomerular filtration rate. The researchers did not find a connection between the diagnosis of CKD and the severity of the patient’s pulmonary hypertension.

This study was one of the first to examine the presence of pulmonary hypertension in the earlier stages of chronic kidney disease. Although the results showed lesser percentages of patients with pulmonary hypertension in the early stages of CKD, there was still a clear connection between the two conditions.

The researchers also found an extensive list of CKD risk factors that seemed to play a role in the development of pulmonary hypertension in association with CKD. The full scope of the mechanisms behind the disorder remains unclear.

The researchers do note that, as the literature of pulmonary hypertension is limited, the varying definitions of the disorder make it difficult for researchers to cross-examine data from multiple studies, as the diagnostic criteria are likely to differ between them.

This also causes problems when it comes to creating any kind of treatment plan or guidelines. Having everyone in the medical world on the same page as to what the condition entails and what the potential treatments are would be beneficial for patients and medical staff moving forward.

Also read: Chronic kidney disease diet: Food list, recommendations, and recipes

Related Reading:

What is the life expectancy with stage 4 kidney disease? Symptoms, treatment, and diet

Stage 3 chronic kidney disease: Symptoms, diet, and treatment


On any matter relating to your health or well-being, please check with an appropriate health professional. No statement herein is to be construed as a diagnosis, treatment, preventative, or cure for any disease, disorder or abnormal physical state. The statements herein have not been evaluated by the Foods and Drugs Administration or Health Canada. Dr. Marchione and the doctors on the Bel Marra Health Editorial Team are compensated by Bel Marra Health for their work in creating content, consulting along with formulating and endorsing products.