West Nile virus (WNV) infection is particularly dangerous for the elderly, raising the numbers of severe cases and even death. The researchers analyzed and compared immune responses to WNV infection in four-month-old and 18-month-old (senior) mice.
The researchers found that the senior mice were three times more likely to die after WNV infection, compared to the four-month-old mice. Older mice had higher concentrations of the infection in the spleen and blood, as well as in their brains – which wasn’t the case for the younger mice.
The researchers concluded that their study “identifies a series of key early defects associated with immune responses in old animals.” As to the mechanisms at work, they explained that “the delayed antibody and germinal center cell responses are due to trafficking defects, which are compounded by lower levels of chemokines in the lymph node after infection. Ultimately, this leads to blunted adaptive immune responses, higher viral titers, and increased death after West Nile virus infection.”
The study reveals that West Nile virus is more threatening and dangerous to the elderly, so seniors should take extra precautions to minimize their risk of contracting the mosquito-transmitted virus.
Here are some tips to help reduce your risk of mosquito-transmitted infections.
Avoiding areas where mosquitoes breed immediately reduces your risk of any bites. These areas included grassy, wooded areas, still water, and the nighttime hours.
Other measures to better protect yourself and your family include using a mesh netting over strollers and carriages, wearing long loose-fitting clothing, and wearing light-colored clothing to deter insects as well as spot them more easily when they are on you.