Midlife diabetes linked to faster memory loss, cognitive decline, and dementia progression in next 20 years: Study

By: Dr. Victor Marchione | Brain Function | Tuesday, October 11, 2016 - 12:30 PM

Midlife diabetes linked to faster memory loss, cognitive decline, and dementia progression in next 20 years: StudyMidlife diabetes diagnosis is linked to faster memory and cognitive decline and dementia progression during the next 20 years, according to research findings. The researchers found that diabetes ages the mind up to five years faster, compared to normal effects of aging.

Study lead Elizabeth Selvin said, “The lesson is that to have a healthy brain when you’re 70, you need to eat right and exercise when you’re 50. There is a substantial cognitive decline associated with diabetes, pre-diabetes, and poor glucose control in people with diabetes. And we know how to prevent or delay the diabetes associated with this decline.”

The researchers used data from Atherosclerosis Risk in Communities Study (ARIC), which followed 15,792 middle-aged adults. There were four follow-up visits, three years apart, and then the fifth follow-up was between 2011 and 2013. Cognitive function was evaluated on the visit two and visit five.

The researchers compared the scope of cognitive decline associated with aging and the scope of cognitive decline in the study subjects. They found that patients with uncontrolled diabetes had 19 percent greater cognitive decline.

Selvin added, “If we can do a better job at preventing diabetes and controlling diabetes, we can prevent the progression to dementia for many people. Even delaying dementia by a few years could have a huge impact on the population, from quality of life to healthcare costs.”

Coauthor A. Richey Sharrett added, “There are many ways we can reduce the impact of cerebral blood vessel disease — by prevention or control of diabetes and hypertension, reduction in smoking, increase in exercise, and improvements in diet. Knowing that the risk for cognitive impairments begins with diabetes and other risk factors in midlife can be a strong motivator for patients and their doctors to adopt and maintain long-term healthy practices.”

Cognitive decline may be prevented by managing or delaying onset of diabetes

In an alternative study, researchers found that preventing or effectively managing diabetes can help delay or manage cognitive decline. The study included over 3,069 adults over the age of 70 who provided periodic blood samples and took regular cognitive tests during the study period.

At the beginning of the study, hundreds of the patients had diabetes. After a decade, more participants developed diabetes along with cognitive decline.

Those who had diabetes at the start of the study showed a faster cognitive decline, compared to those who developed diabetes during the study. These patients fared much worse than those who never developed diabetes.

Although the study highlights a link between diabetes and cognitive decline, how the two are associated is still very much unclear. It may have to do with insulin degrading enzyme present in both diabetes and dementia. Instrumental in insulin regulation, this enzyme also degrades beta-amyloid in the brain, a protein associated with cognitive decline.

Additional research is required to better understand this association and find helpful ways of effective cognitive decline prevention.

In the meantime, it is imperative that you reduce your risk of diabetes or properly manage the condition if you do have it.


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Sources:

http://www.ucsf.edu/news/2012/06/12216/preventing-or-better-managing-diabetes-may-prevent-cognitive-decline-according
http://annals.org/article.aspx?articleid=1983393

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