Brain injury early in life associated with dementia later on: Study

By: Mohan Garikiparithi | Brain Function | Friday, July 07, 2017 - 06:00 AM

brain injury early in lifeYoung people tend to take more risks in life, especially when it comes to their safety and well-being. Speeding down highways, bungee jumping off bridges, and even skydiving all seem thrilling, but they also come with the risk of serious injury or death.

A new study from Finland has found a correlation with severe head injury, especially during middle age, and increased risk of developing dementia later in life.

Head injuries are a common occurrence

About 1.7 million Americans experience some sort of traumatic brain injury each year, often from falls, car accidents, and gun use. About one-in-three people who suffer from moderate to severe brain damage die from their injury.

The researchers followed people who have suffered a traumatic brain injury [TBI] at age 65 or younger to see if there would be any changes in the memory, thinking, or behavior over time.

Dementia risk increased

Not only did the risk for dementia increase in traumatic brain injury patients, but the severity of the brain injury was seen to boost the risk of dementia development.

“The study showed that 3.5 percent of persons with moderate-to-severe TBI [were] diagnosed with a neurodegenerative disease [such as dementia] later in life. Only 1.6 percent of persons with mild TBI were diagnosed with a neurodegenerative disease,” said study lead author Dr. Rahul Raj.

This means that people with moderate to severe traumatic brain injury are at 90 percent greater risk than people considered to have mild brain trauma. However, the researchers stress that their study could not prove a direct cause-and-effect between traumatic brain injury and dementia.

Looking at brain injury patients

The study involved more than 40,000 adults between the ages of 18 and 65, all of which had been hospitalized with mild, moderate, or severe traumatic brain injuries between the years 1987 and 2014.

More than half the subjects had sustained a moderate to severe traumatic brain injury, being hospitalized for a minimum of three days and diagnosed with some sort of serious brain lesion.

The other half of the subjects, considered to only have a mild traumatic brain injury, were hospitalized for less than a day and had no evidence of a brain lesion.

Above average dementia risk was found in all study participants, however, those with moderate to severe TBI had a substantially higher risk in comparison.

TBI victims between 41 to 50 saw their odds of dementia triple compared to mild injury. Those aged 51 to 60 saw their odds of dementia double. Individuals in the moderate to severe TBI group were more likely to end up with dementia before 65 compared to the mild TBI group—40 percent vs. 26 percent, respectively.

“Even after [a] seemingly [full] recovery, there is an underlying elevated risk for dementia that probably won’t ever go away. Thus, until we have a specific treatment for this, it is extremely important to minimize other risk factors for dementia, such as high blood pressure, high levels of cholesterol, diabetes, tobacco smoking and alcohol consumption,” said Raj.

Related: A childhood head injury can haunt you years later


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Related Reading:

Concussion (traumatic brain injury) and head impact may accelerate brain aging

Ischemic stroke risk linked to traumatic brain injury (TBI), independent of other factors

Sources:

https://www.helsinki.fi/en/news/traumatic-brain-injury-associated-with-dementia-in-working-age-adults

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